Central nervous system
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Central nervous system - Leaderboard
Central nervous system - Details
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81 questions
| 🇬🇧 | 🇬🇧 |
| Amitriptyline | Elavil Tricyclic antidepressant |
| Trazodone | Desyrel, Oleptro Serotonin antagonist + reuptake inhibitor |
| Bupropion | Wellbutrin, Zyban Norepinephrine-dopamine reuptake inhibitor |
| Citalopram | Celexa SSRI |
| Desvenlafaxine | Pristiq SNRI |
| Doxepin | Silenor Tricyclic antidepressant |
| Duloxetine | Cymbalta SNRI |
| Escitalopram | Lexapro SSRI |
| Fluoxetine | Prozac, Sarafem SSRI |
| Mirtazapine | Remeron Tetracyclic antidepressant |
| Nortriptyline | Pamelor Tricyclic antidepressant |
| Paroxetine | Paxil SSRI |
| Sertraline | Zoloft SSRI |
| Vilazodone | Viibryd SSRI/5-HT1a receptor partial agonist |
| Venlafaxine | Effexor SNRI |
| Atomoxetine | Strattera Norepinephrine reptile inhibitor ( ADHD) |
| Amphetamine-Dextroamphetamine | Adrenal, Mydaylis CNS stimulant |
| Dexmethylphenidate | Focalin CNS stimulants |
| Lisdexamfemtamine | Vyvanse CNS stimulant |
| Methylphenidate | Ritalin, Concerta, Metadate ER CNS stimulant |
| Modafinil | Provigil CNS stimulant |
| Phentermine | Adipex-P, Lomaira CNS stimulant + anorexiant |
| Atomoxetine | Strattera Norepinephrine reuptake inhibitor (ADHD) |
| Amphetamine-dextroamphetamine | Adderall, Mydalis CNS stimulant |
| Dexmethylphenidate | Focalin CNS stimulant |
| Lisdexamfetamine | Vyvanse CNS stimulant |
| Methylphenidate | Ritalin, Concerta, Metadate ER CNS Stimulant |
| Modafinil | Provigil CNS Stimulant |
| Phentermine | Adipex-P, Lomaira CNS stimulant + anorexiant |
| Alprazolam | Xanax Benzodiazepine |
| Buspirone | Buspar anti-anxiety agent |
| Clonazepam | Klonopin Benzodiazepine |
| Diazepam | Valium, Diasts, Valtoco Benzodiazepine |
| Hydroxyzine | Atarax, Vistaril H1 antagonist |
| Lorazepem | Ativan Benzodiazepine |
| Aripiprazole | Abilify Antipsychotic |
| Haloperidol | Haldol Antipsychotic |
| Lurasidone | Latuda Antipsychotic |
| Olanzapine | Zyprexa Antipsychotic |
| Quetiapine | Seroquel Antipsychotic |
| Risperidone | Risperdal Antipsychotic |
| Ziprasidone | Geodon Antipsychotic |
| Eszopiclone | Lunesta Hypnotic (sleep) |
| Zolpidem | Ambien, Edluar, Intermezzo Hypnotic (sleep) |
| Temazepam | Restoril Benzodiazepine |
| Carbamazepine | Tegretol, Carbatrol, Epitol, Equetro Anticonvulsant |
| Divalproex sodium | Depakote Anticonvulsant |
| Gabapentin | Neurontin, Gralise Anticonvulsant |
| Lamotrigine | Lamictal Anticonvulsant |
| Levetiracetam | Keppra, Elepsia XR, Roweepra, Spritam Anticonvulsant |
| Oxcarbazepine | Trileptal Anticonvulsant |
| Phenytoin | Dilantin, Phenytek Anticonvulsant |
| Pregabalin | Lyrica Anticonvulsant |
| Topiramate | Topamax, Qudexy XR, Trokendi XR Anticonvulsant |
| Carbidopa-levodopa | Sinemet, Duopa, Rytary Anti-Parkinson's agent |
| Donepezil | Aricept Cholinesterase inhibitor |
| Lithium carbonate | Lithobid, Eskalith Antimanic |
| Memantine | Namenda NMDA receptor antagonist |
| Pramipexole | Mirapex Dopamine agonist |
| Ropinirole | Requip Dopamine agonist |
| Sumatriptan | Imitrex, Onzetra Xsail, Tosymra Serotonin receptor agonist |
| Varenicline | Chantix Partial nicotine agonist |
| Bimatoprost | Lumigan Prostaglandin analog |
| Brimonidine | Alphagan P Alpha2-agonist (opthalmic) |
| Dorzolamide-timolol | Cosopt combination carbonic anhydrase inhibitor + β-blocker |
| Latanoprost | Xalatan, Xelpros Prostaglandin analog |
| Timolol | Timoptic, Betimol, Istalol β1/β2-blocker |
| Travoprost | Travatan Z Prostaglandin analog |
| MOA of SSRI | Selectively inhibit reuptake of serotonin, may also desensitize presynaptic serotonin receptors in a negative feedback loop that normally inhibits serotonin release// abrupt stopping may result into rebound depression |
| MOA of TCA | Inhibit reuptake of NE and serotonin, basically a more potent inhibitor of NE |
| Common side effects of TCA | Anti cholinergic, increase IOP, difficulty urinating, dry mouth and constipation |
| MOA of SNRI | Inhibits reuptake NE and serotonin, more potent inhibitor of serotonin (similar to TCA but less anti cholinergic) |
| Facts for Venlafaxine (Effexor) | Dose dependent effect on BP, substrate (major) 206 and 3A4 and weak inhibitor for 2B6, 2D6, 3A4 |
| Facts for Desvenlafaxine | Active metabolite of Venlafaxine and more than 50 mg can confer little benefit |
| Facts for duloxetine (Cymbalta) | Can also be used for diabetic neuropathy and fibromyalgia, N/V, use caution with patients with gastroparesis |
| Common ADRs with duloxetine (Cymbalta) | Initial changes in BP, lowers seizure threshold, N/V, HA, xerostoma. And sexual dysfunction |
| Fact for Citalopram (Celexa) | Max dose of 20mg, racemic mixture, NOT approved for children and caution for hepatic impairment due to conc dependent QT prolongation |
| Facts for Escitalopram (Lexapro) | S enantiomer, avoid within 2 weeks of MAOi |
| Facts of fluoxetine (Prozac, sarafem) | Metabolized to Norfluoxetine, stop MAOi for 14 WEEKS!, or start MAOi 5 weeks after stopping fluoxetine, also used for fibromyalgia, panic disorder, PTSD, Reynauds phenomena, and social anxiety disorder |
| Which antidepressant is contraindicated with Thioridazine or primozide | Fluoxetine (Prozac, sarafem) |
| Facts for Paroxetine (Paxil) | One of the most sedating and anti cholinergic SSRI, WEIGHT GAIN, limit dose in hepatic impairment |
| Facts for Sertraline (Zoloft) | Reduce dose for liver impairment, may cause FALSE POSITIVE FOR BENZOS, safe for 6 years, more useful in the elderly |
| Fact of vilazodone (Viibryd) | Unique mechanism- partial 5HT1A agonist |
| Least likely to interact with CYP450 | Citalopram and Escitalopram |
| Well known inhibitors of CYP2D6 (antidepressants) | Fluoxetine and paroxetine |