| What is a septic shock | Dramatic drop in blood pressure which can lead to organ problems and death |
| What does inflammation do | Vasodilation, increases vascular permeability to allow leukocytes to enter the site of infection. |
| What is hypovolaemia | Loss of blood volume relating to blood loss or plasma loss |
| What does obstruction of the capillary cause | Decreased oxygen delivery/ removal of waste products which can lead to multiple/single organ failure |
| How does Systemic inflammation play a part in coagulation | Tissue factor mediated and starts thrombin generation, inhibits anticoagulant mechanism/fibrinolysis |
| To recognise sepsis what do you use | TIME ( Temperature, Infection , Mental decline , extremely ill ) |
| Why does gram-ive bacteria are the main cause of sepsis? | They contain LPS ( lipopolysacchiride ) which activates macrophages and NK cells |
| Why are the SIRS not used anymore in modern practise | Poor senstivity and specificity |
| What is now used and what score is needed | SOFA ( Sequential Organ Failure Assesment ) , needs an increase of 2 or more to have sepsis |
| What is the sepsis 6 bundle? | Give oxygen, take cultures , broad antibiotics, IV fluids, take lactate levels and urine outputs |
| What can result in after absolute hypovolaemia | Decrease in systemic vascular resistance which can lead to decrease BP |
| What causes absolute hypovolaemia | Leakage in the capillaries causing reduced blood volume and decrease in cardiac output and systemic vascular resistance which can lead to less oxygen and hypoxia. |
| During sepsis what happens to coagulation? | It is accelerated leading to tiny blood clots forming in capillaries |
