| Penicllins | First choice of drug for bone and joint infections, given IM or IV |
| Cephalosporins- | Similar pharmacology to penicillin |
| How have bacteria adapted agaisnt such antibiotics | Beta lactomases- nearly all gram negative bacteria, production of membrane permebilility |
| How do tetracylins work | Block T-rna binding to the ribosomal unit |
| What can tetracyclines cause in teeth | Tetracycline staining or dental hypoplasia |
| How do aminoglycocides work | Attach to mRNA during translation chanigng anticodon recognition therefore non functional protein produced |
| How does erythromyocin work | Prevents tRNA molecucle moving from the A side to the T side of the ribosome |
| When is erthromyocin normally given | When patient has a sensitivity to penicillin |
| Clindamycin is a broad spectrum antibiotic given in caution why? | Can clear the large intestine of its natural bacteria which can allow clostridium difficile to grow and cause severe problems |
| Metronidazol 3 features | Cytotoxic products destroy cells, is effective against anaerobes and protozoa but has side effects of nausea and metallic taste. Also has disulfram- like reaction with alchohol |
| When should antibiotics be given | Persistent advanced infections, complex gum or implant work, patients with weak immune system and prevention of endocarditiis |
| What is granulomatosis with polyangitis | Nose and paranasal sinuses inflammation and bleeding- thought to be an autoimmune disease |
| What is rhinohhorea | 'Runny nose' |
| What is haemoptysis | Coughing up blood |
| What is epstein barr syndrome | Mono" causes glandular fever |
