level: Level 1
Questions and Answers List
level questions: Level 1
| Question | Answer |
|---|---|
| a chemistry-based discipline, involving aspects of biological, medical and pharmaceutical sciences. It is concerned with the invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation of their mode of action at the molecular level and the construction of structure-activity relationships (SARs). | Medicinal chemistry |
| Structure determines function The structure of a compound determines the biological effects it has. | Structure-Activity Relationships |
| Medicinal chemistry also involves the discovery of __ for the treatment of diseases and the systematic study of the structure-activity relationships of the active compounds. | New chemical entities |
| is the relationship between chemical structure and pharmacological activity for a series of compounds. | Structure-activity relationship (SAR) |
| is a compound that has a desirable biological activity with therapeutic relevance, but typically has some shortcoming that is likely to be overcome through the development of analogs. | Lead compound |
| Drug Discovery Cycle | 1 Compound Collections 2 Primary Assays 3 Secondary Assays 4 Lead Compounds and SAR 5 Structural Characterization of Protein-Ligand Complex 6 Design 7 Chemical Synthesis 8 Clinical Candidate |
| is any substance presented for treating, curing or preventing disease in human beings or in animals. It may also be used for making a medical diagnosis or for restoring, correcting, or modifying physiological functions. | Drug |
| Drug Emphasis | 1. Chemically structural feature, physico-chemical property, stability. 2. Biological effect, adverse effects, biotransformation etc. 3. Structure-activity relationship, drug targets in living bodies as well as mode of action. |
| The important role of Drugs in human society | Improving both the individual quality of life and life expectancy. 1. Bacterial and virus infections: polio, smallpox, tuberculosis and related diseases have, to a very major extent, become minor public health concerns. 2. An increase in life expectancy resulting from drug therapy has also led to a shift in population demographics toward a more healthy, elderly population. 3. Drug regimens for birth control have improved individual life choices and the quality of life. 4. HIV protease and reverse transcriptase inhibitors for the treatment of HIV infections have changed a disease with a fatal prognosis to a potentially chronic one. 5. Cancer is also being viewed as a potentially chronic, rather than fatal disease with newer, non-cytotoxic approaches. |