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level: NITROFURANS

Questions and Answers List

level questions: NITROFURANS

Question	Answer
First nitroheterocyclic compounds to be introduced	Nitrofurazone Furazolidone Nitrofurantoin
tx of bacterial infections	Nitrofurazone Furazolidone Nitrofurantoin
antiprotozoal agent to treat trypanosomiasis and leishmaniasis	Nifurtimox
amebicide, tx of systemic infections caused by anerobic bacteria	Metronidazole
>Antimicrobial activity is present only at 5-position > Mutagenic and carcinogenic	Derivatives of 5-nitro-2-furaldehyde
5-nitro-2-furaldehyde semicarbazone Topical: tx of burns Broad spectrum P. aeruginosa: resistant 0.2%: solutions, ointments, suppositories	Nitrofurazone (Furacin)
3-[(5-Nitrofurylidene)amino]-2-oxazolidone Oral tx of bacterial or protozoal diarrhea caused by susceptible organisms (S. aureus, E. coli, Salmonella, Shigella, Proteus, Enterobacter, V. cholera) CI: alcohol-inhibit aldehyde dehydrogenase	Furazolidone (Furoxone)
1-(5-nitro-2-furfurylidene)-1-aminohydantoin Oral use used as urinary antiseptic S/E: GI (N/V),anorexia hypersensitivity rxns	Nitrofurantoin ( Furadantin, Macrodantin)
2-methyl-5-nitroimidazole-1-ethanol Drug Of Choice for E. histolytica, G. lamblia, T. vaginalis Unpleasant metallic taste if taken with alcohol, Disulfiram like effect	Metronidazole ( Flagyl)
Prepared by evaporation of a solution of formaldehyde and strong ammonia water to dryness Urinary antiseptic of chronic UTI Taken with sodium bisphosphonate or ammonium chloride, urease inhibitor (acetohydroxamic acid, (Lithostat)	Hexamethylenetetramine (Urotropin, Uritone) It is a Methenamine and its Salts
Methenamine and its Salts	1 Methenamine mandelate 2 Methenamine hippurate
2,6-diamino-3-(phenylazopyridine HCl) tx for pain and discomfort ass. with UTI given in combination with urinary antiseptics	Urinary Analgesic: Phenazopyridine HCl (Pyridium)