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level: ANTI TUBERCULAR and ANTILEPROSY DRUGS MODE OF ACTION

Questions and Answers List

level questions: ANTI TUBERCULAR and ANTILEPROSY DRUGS MODE OF ACTION

QuestionAnswer
1 Isoniazid Mode of Action1 Inhibits synthesis of mycolic acid
1 Rifampin & Rifabutin Mode of Action1 Binds to B subunit of DNA-dependant RNA Polymerase and inhibit it
1 Ethambutol Mode of Action1 Inhibits Arabinosyl Transferase enzyme and prevent polymerization of arabinoglycans
1 Pyrazinamide Mode of Action1 Activated to pyrazionic acid under acidic conditions 2 Inhibits Mycobacterial fatty acid synthase-1 Enzyme and disrupts mycolic acid synthesis 3 Binds to ribosomal proteins S1 and inhibits translation
1 Antileprosy Drugs 2 Mode of Action of these drugs1) 1 Dapsone 2 Clofazimine 2 Dapsone: Inhibits Folic acid synthesis Clofazimine: Binds to mycobacterial DNA & Inhibit Bacterial Growth