You are in browse mode. You must login to use MEMORY

level: level 3

Questions and Answers List

level questions: level 3

Question	Answer
Usual adult oral suspension is designed to supply the dose of a particular drug in a convenient measure of __	5mL or 1 teaspoonful
are formulated to deliver the appropriate dose of drug by administering a DOSE-CALIBRATED NUMBER OF DROPS or with the use of a teaspoon.	Pediatric suspensions
employed as wetting agents when aqueous vehicles are to be used as dispersion phases.	Alcohol, glycerin, propylene glycol
1 Used in large scale preparations of suspensions 2 Small scale	1 Colloid mill 2 mortar & pestle.
Preservatives for suspensions (Antacid Aluminum Hydroxide)	1 methylparaben 2 propylparaben
Difficult to maintaining the stability of this suspension	Sustained-Release Suspensions
1 use of combination of ion exchange resins and particle coating 2 are complexed with ion exchange resins and the drug-resin complex particles coated with ethylcellulose	1 Pennkinetic system 2 ionic drugs
In liquid formulations (suspensions), the drug remains absorbed onto the resin but is slowly released by the ion exchange process in the GIT EXAMPLE PRODUCT:	Hydrocodone polistirex (Tussionex Pennkinetic Extended-release suspension, Medeva)
Extemporaneous Compounding of Suspensions	• Not all medicines are available in a convenient, easy to take liquid dosage form • Special considerations are needed for infants and elderly and other who cannot take solid dosage forms • lack of ready information on stability of a drug in liquid vehicle
most stable in milk or antacid and is unstable in acidic solutions when compounded from crushed tablets or the injectable form	Leucovorin Calcium
Drugs with extemporaneous formulations in literature	• Prednisone oral suspension • Ketoconazole suspension
journal wherein hundreds of compounded liquid formulations, based upon documented stability data are available	International Journal of Pharmaceutical Compounding
Typical Compounding of Suspensions (step by step)	1 Contents of capsule are crushed in a mortar w/ a pestle 2 Add vehicle to the mix, mix with powdered mixture (paste) 3 dilute with desired volume ( Ora-sweet, Orasweet SD, Ora-Plus, Ora-blend
Liquid suspensions for __ should not include preservatives, colorings, flavorings or alcohol because of the potential for each of these to cause either acute or long term adverse effects flavoring agent is not required	Neonates
can alter liver functions, cause gastric irritation and effect neurologic depression	Alcohol (Aromatic Elixir NF)