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level: level 10

Questions and Answers List

level questions: level 10

Question	Answer
FLUORINATED HYDROCARBON GASES may be liquefied by cooling below their boiling points or by compressing the gas at room temperature. These 2 features are utilized in the filling of aerosol containers with propellant.	Filling Operations
Both the product concentrate and the propellant must be cooled to temperatures of -30 to -40 F. This temperature is necessary to liquefy the propellant gas. The cooling system may be a mixture of dry ice and acetone.	Cold Filling
The product concentrate is quantitatively placed in the aerosol container, the valve assembly is inserted and crimped into place, and liquefied gas, under pressure, is metered into the valve stem from a pressure burette.	Pressure Filling
Testing the Filled Containers	1. Leaks 2. Weakness in the valve assembly or container 3. Proper function s of the valve 4. The valve discharge rate - determine by discharging a portion of the contents of a previously weighed aerosol during a given period of time, and calculating, by the difference in weight, the grams of contents discharged per unit of time. 5. Particle size distribution of the spray 6. For accuracy and reproducibility of dosage when using metered valves
Aerosols packages for topical use on the skin include: 1 Antiinfectives	. 1 Povidone - iodine, 2 Tolnaftate 3 Thimerosal
Aerosols packages for topical use on the skin include: 1 Adrenocortical steroids	. 1 Betamethasone 2 Triamcinolone acetonide
Aerosols packages for topical use on the skin include: 1 Local anesthetic	Dibucaine hydrochloride
an emulsion dosage form containing dispersed gas bubbles. When dispensed, it has a fluffy, semisolid consistency.	FOAMS
are emulsions containing a dispersed phase of gas bubbles in a liquid continuous phase containing the active pharmaceutical ingredient. are packaged in pressurized containers or special dispensing devices and are intended for application to the skin or mucous membranes.	Medicated foams
Preparation of FOAMS , 1 If the propellant is in the internal or discontinuous phase, __ is discharged 2 If the propellant is in the external or continuous phase, __ is discharged	1 Stable foam 2 Quick-breaking foam