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level: Aminoglycoside SAR

Questions and Answers List

Question	Answer
1 Important for broad spectrum activity, at the same time, major site for enzymatic inactivation by AAC and APH 2 Amino group at __ and __ are important 3 __ will reduce the binding to ribosomes 30S subunit	1 Ring I 2) 6 & 2 3 Phosphorylation at 3 OH
Can accept few structural modification Can be ribose, streptose or streptamine	Ring II
1 Less sensitive to structural changes 2 BUT the amino group at position 3 can be __ for maximum activity	1 Ring III 2 primary or secondary