level: Tetracycline Chemical Stability
Questions and Answers List
level questions: Tetracycline Chemical Stability
| Question | Answer |
|---|---|
| Action of acids (Strong acids) 1 Dehydration at Carbon __ 2 Aromatization of __ 3 During action of acids, Tetracycline turns into inactive form __ | . 1) 6 2) Ring C 3 Anhydrotetracycline |
| Dehydration in acidic medium Nephrotoxic degradation product | 4-Epianhydrotetracyclines |
| 1 Occur at PH= 2-6 especially in solutions (weak acids) 2 Leads to the formation of inactive form __ | 1 Epimerization 2) 4-Epitetracycline (B-configuration) |
| Action of bases 1 Cleavage of ring C in tetracyclines having __ 2 Produces lactonic product, inactive form __ | . 1) 6-OH 2 Isotetracycline |
| Resist action acid and base Higher lipid solubility & better absorption | Tetracyclines with no 6-OH |
| 1 Tetracyclines form insoluble non-absorbable salts in the GIT 2 Incompatible with __ | 1 Chelation 2 Milk, Antacids, Anti-anemics |