level: Level 1
Questions and Answers List
level questions: Level 1
| Question | Answer |
|---|---|
| Macrolide Chemistry | a large lactone ring a ketone group a glycosidically linked sugar |
| The lactone ring usually has __ atoms and is often unsaturated & conjugated with the ketone group | 12, 14, or 16 |
| Having a dimethyl amino group on the glycone part, macrolide antibiotics are __ AND different salts with pKa range of (6-9) can be formed on the __ group. | weak bases, amino |
| Macrolides are 1 Macrolides are __ molecules 2 Macrolides are stable in __ 3 They are unstable in __ | . 1 water-insoluble 2 aqueous solutions at or below room temperature 3 acidic or basic conditions or at high temperatures |
| Tetracycline Mechanism of Action | 1 Inhibits protein synthesis by reversibly binding to 50s ribosomal unit 2 Suppression of RNA dependent protein synthesis by inhibition of translocation of mRNA |
| Macrolide Resistance | 1 Target gene mutation especially the erg gene 2 Efflux pump 3 Methylation at the 50s ribosomal subunit 4 Unable to penetrate the cell wall of gram negative bacilli |
| 1 Macrolides are frequently active against bacterial strains that are resistant to __ 2 Macrolide spectrum of activity resembles with Penicillin but also effective against | 1 penicillins 2 mycoplasma, Chlamydia, Campylobacter, Legionella |