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level: Level 3

Questions and Answers List

Specific Agents

level questions: Level 3

QuestionAnswer
Have a tricyclic structure in which TWO BENZENE RINGS are linked by a sulfur and a nitrogen atomPHENOTHIAZINES
Types PHENOTHIAZINES• ALIPHATIC - Chlorpromazine • PIPERAZINE - Fluphenazine, Prochlorperazine • PIPERIDINE - Thioridazine
• FIRST PHENOTHIAZINE COMPOUND introduced in therapy • used to treat INTRACTABLE HICCUPS ALIPHATICChlorpromazine • Thorazine®
1 •Sparine® 2 •Vesprin® 3 • Mellaril® (PIPERIDINE) 4 •Serentil®1 Promazine 2 Triflupromazine 3 Thioridazine 4 Mesoridazine
Promote ARRYTHMIA HIGHEST RISK for QT INTERVAL Has been issued with BLACK BOX WARNING May lead to BLINDNESS due to retinal depositsThioridazine
• MAINLY used for its ANTI-EMETIC EFFECT rather than as antipsychotic agent Treatment of drug-induced NAUSEA PIPERAZINEProchlorperazine • Compazine®
• an effective ANTIPSYCHOTIC AND ANTIEMETICPerphenazine
• the most POTENT antipsychotic PHENOTHIAZINE •HIGHEST RISK OF EXTRAPYRAMIDAL SYMPTOMS PIPERAZINEFluphenazine • Permitil®, Prolixin®
• DIFFERS FROM THE PHENOTHIAZINE SYSTEM by replacement of the N-H moiety with a carbon atom doubly bonded to the propylidine side chain THIOXANTHENEThiothixene • Navane®
• a POTENT antipsychotic USEFUL IN SCHIZOPHRENIA and in psychoses associated with BRAIN DAMAGE frequently chosen to TERMINATE MANIA and often used in therapy for GILLES DE LA TOURETTE BUTYROPHENONEHaloperidol • Haldol®
• may be used alone as a PREANESTHETIC NEUROLEPTIC or as ANTIEMETIC BUTYROPHENONEDroperidol • Inapsine®