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level: Level 4

Questions and Answers List

ATYPICAL DRUGS: Ring Analogs of Phenothiazines

Question	Answer
1 • Daxolin® 2 • Seroquel® 3 • Risperdal®	1 Loxapine 2 Quetiapine 3 Risperidone
• has proved EFFECTIVE even in CHRONICALLY ILL PATIENTS who respond POORLY TO STANDARD NEUROLEPTICS • used to reduce SUICIDAL RISK ONLY drug that does not cause EPS • S/E: SEVERE AGRANULOCYTOSIS, seizure, myocarditis	Clozapine • Clozaril®
Management of DISRUPTIVE BEHAVIOUR and IRRITABILITY secondary to AUTISM	Risperidone
• a more potent antagonist at D2 and 5- HT2A receptors • can INDUCE WEIGHT GAIN, TYPE 2 DIABETES & HYPERLIPIDEMIA	Olanzapine • Zyprexa®
• can cause/PROMOTE ARRYTHMIA	Ziprasidone •Geodon®
Management of DISRUPTIVE BEHAVIOUR and IRRITABILITY secondary autism • DOPAMINE AGONIST-ANTAGONIST • NEWEST antipsychotic agent • LESSER WEIGHT GAIN	Aripiprazole • Abilify®
Treatment for BIPOLAR DISORDER Available as SUBLINGUAL	Asenapine
Used in SCHIZOAFFECTIVE DISORDER	Paliperidone
Treatment for BIPOLAR disorder ADJUNCTIVE treatment for MAJOR DEPRESSION also causes SEDATION (strong antihistaminergic effect)	Quetiapine
The administration of this minimizes EXTRAPYRAMIDAL EFFECTS (more effective for pseudoparkinsonism and acute dystonia) Anticholinergic	Benztropine
DRUG OF CHOICE for management of ANTIPSYCHOTIC-INDUCED AKATHISIA	Propranolol