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level: Effects of Prostaglandins & Thromboxanes PART 2

Questions and Answers List

Question	Answer
In, Central & Peripheral NS FEVER 1 increases body temperature 2 Endogenous pyrogens release __, which in turn promotes the synthesis of PGE2	. 1 PGE2 2 interleukin-1
Synthesis of INTERLEUKIN-1 is blocked by __	ASPIRIN and other antipyretic compounds
SLEEP 1 induces natural sleep 2 causes wakefulness	. 1 PGD2 2 PGE2
NEUROTRANSMISSION 1 inhibit the release of NE (Norepinephrine) 2 Thus, __ increase NE release that explains the vasoconstriction observed during treatment	. 1 PGE2 2 NSAIDs
In Inflammation & Immunity, 1 PREDOMINANT PROSTANOIDS associated with inflammation enhance EDEMA FORMATION and LEUKOCYTE INFILTRATION by promoting blood flow in the inflamed region	. 1 PGE2 & PGI2
In Bone Metabolism, 1 stimulates bone resorption and formation	. 1 prostaglandins
facilitates TUMOR INITIATION, PROGRESSION and METASTASIS through multiple biologic effects, INCREASING PROLIFERATION and ANGIOGENESIS, inhibiting apoptosis, augmenting cellular invasiveness and modulating immunosuppression	Prostaglandins (PGE2)