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level: Level 3

Questions and Answers List

Question	Answer
Antiplatelet Drugs	1 Aspirin (ASA) 2 Ticlopidine [Ticlid] 3 Clopidogrel [Plavix] 4 Glycoprotein (GP) IIb/IIIa receptor antagonists
Inhibition of cyclooxygenase Adverse effect: Increase risk of GI bleeding	Aspirin (ASA)
Inhibits ADP-mediated aggregation Adverse effects: Hematologic effects	Ticlopidine [Ticlid]
ADP receptor antagonist	Clopidogrel [Plavix]
Most effective antiplatelet drugs especially in acute coronary syndromes • Reversible blockade of platelet GP IIb/IIIa receptors EXAMPLE: ABCIXIMAB	Glycoprotein (GP) IIb/IIIa receptor antagonists
Drugs that break down, or lyse, preformed clots	Thrombolytic Drugs
Thrombolytic Binds plasminogen Uses: • Myocardial infarction • Deep vein thrombosis • Massive pulmonary emboli Adverse effects • Bleeding • Antibody production • Hypotension • Fever	Streptokinase
Thrombolytic drugs: New compounds	• anistreplase (Eminase) • alteplase (t-PA, Activase) • reteplase (Retavase) • tenecteplase (TNKase)
Thrombolytic Drugs Indications	• Acute MI • Arterial thrombolysis • DVT • Occlusion of shunts or catheters • Pulmonary embolus • Acute ischemic stroke
Thrombolytic Drugs Adverse effects	• Bleeding- Internal, Intracranial, Superficial Other effects • Nausea, vomiting, hypotension, anaphylactic reactions • Cardiac dysrrhythmias; can be dangerous