1. DRY MIXING of ingredients to achieve homogenous powder dispersion.
2. WET MASSING to produce a sufficiently plastic wet mass.
3. EXTRUSION (pushing the wet mass into a dye) to form rod-shaped particles to form uniform size
and diameter; The extrude produced must have
enough plasticity to deform but not so much that
the extruded particles adhere to other particles
when collected or rolled in the spheronizer
4 SPHERONIZATION (transition from cylindrical particles
into cylindrical particles with rounded edges, into
dumbell shape, into ellipsoids, and finally into
sphere)
5 DRYING to achieve the desired moisture content
6 SCREENING; achieve the desired narrow size distrib.
1 UNCOATED PELLETS:
uniform spherical shape,
uniform size,
good flow properties,
reproducible packing into hard gelatin capsules,
high strength,
low friability,
low dust,
smooth surface,
ease of coating
2 ONCE COATED:
o Desired drug-release characteristics
o Once coated, they will maintain the
properties in uncoated pellets
