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Index
»
PHARMACOLOGY 2
»
wk12-13 Antimicrobials,antifungals.pptx
»
Level 6 - VIDEO LEC
level: Level 6 - VIDEO LEC
Questions and Answers List
level questions: Level 6 - VIDEO LEC
Question
Answer
1 the bacteria we have a __. We can have __ being synthesized and __ here. 2 synthesize proteins.
1) 1 circular DNA 2 RNA 3 ribosomes 2 ribosomes
ones that target the cell membrane. antibiotics that disrupt the cell membrane function (they disrupt the phospholipid bilayer) binds to the cell membrane, ;alter the cell membrane structure; disrupt the osmotic balance; leakage of cellular molecules; result to cell death
DISRUPTION OF CELL MEMBRANE FUNCTION-
DISRUPTION OF CELL MEMBRANE FUNCTION (CELL MEMBRANE INHIBITORS) 1 DRUGS
1 polymixins 2 polyenes
are SPECIFICALLY USED AGAINST FUNGAL PATHOGENS used to target some cell membranes impact in fungus.
Polyenes (Antifungal)
bactericidal; inhibit cell wall synthesis; won't affect human cells because human cells do not have peptidoglycans.
Cell Wall Synthesis Inhibitors
Cell Wall Synthesis Inhibitors 1 DRUGS
1 penicillin 2 cephalosporin 3 bacitracin Beta-lactams: 1 penicillin 2 cephalosporin
1 Drugs that inhibit DNA synthesis: 2 Drugs that inhibit RNA synthesis
1 ■ quinolones ■ Nalidixic acid 2 ■ Rifamycin
are antibiotics that target either the 30s subunit or the 50s; bacteriostatic,
Protein Synthesis Inhibitors
1 Drugs that target 50s subunit: 2 Drugs that target 30s subunit:
1 ○ erythromycin ○ chloramphenicol 2 ○ tetracycline ○ streptomycin ○ gentamycin
1 a PRECURSOR TO FOLATE so the bacteria can metabolize it into folate. 2 folic acid or folate is essential for the synthesis of __, two of the four nucleic acids that make up DNA.
1 PABA para-aminobenzoic acid 2 Adenine and Thymine
Drugs that inhibit folic acid metabolism
○ Sulfonamide ○ Trimetoprim