level: Level 11
Questions and Answers List
level questions: Level 11
| Question | Answer |
|---|---|
| antimicrobial agents that target nucleic acid synthesis | ○ Metronidazole ○ Quinolones ○ Rifamycins |
| a prodrug that requires reductive activation of its nitro group. | METRONIDAZOLE |
| MOA involves interactions with topoisomerases | QUINOLONES |
| two principal topoisomerases that perform this task | ○ DNA gyrase- which unwinds and relaxes supercoiled DNA ○ Topoisomerase 4- which facilitates separation of the linked daughter DNA molecules after replication is complete. |
| examples of Fluoroquinolones are: | ■ Ciprofloxacin ■ Levofloxacin ■ Moxifloxacin ■ Norfloxacin ■ Ofloxacin |
| interfere with transcription of bacterial DNA into RNA Target the enzyme RNA polymerase | RIFAMYCIN |
| RIFAMYCIN drugs | ○ Rifampin ○ Rifabutin ○ Rifapentine |