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level: Level 2

Questions and Answers List

Question	Answer
STUDY OF GENETIC VARIATIONS that influence individual’s response to drugs, and examine polymorphisms that code for drug transporters, drug-metabolizing enzymes and drug receptors.	Pharmacogenetics
1) __ -> severe hypersensitivity, LOW INCIDENCE IN AFRICAN → 2) __ allele present in CAUCASIAN & HISPANIC pts	NRTI’s Abacavir, HLA-B 5701 allele mnemonic: Hi LAB 5701
1)__ Caused by CARBAMAZEPINE and PHENYTOIN → SOUTH ASIAN POPULATION, presence of 2) __ allele	1) 1 Stevens-Johnson Syndrome (SJS) 2 Toxic Epidermal Necrolysis (TEN) 2) HLA-B 1502
Classification of ADR	1 TYPE A - PREDICTABLE, ACUTE, related to MOA 2 TYPE B - IDIOSYNCRATIC, UNPREDICTABLE, ACUTE/SUBACUTE, NOT related to known MOA 3 TYPE C - CHRONIC EFFECTS 4 TYPE D - DELAYED EFFECTS 5 TYPE E - END OF TREATMENT EFFECTS 6 TYPE F - FAILURE of EFFICACY
IDENTIFY WHAT TYPE OF ADR 1 Diarrhea due to antibiotics	. 1 type A (AUGMENTED)
IDENTIFY WHAT TYPE OF ADR 1 HYPERSENSITIVITY due to PENICILLIN	. 1 TYPE B (Bizarre)
IDENTIFY WHAT TYPE OF ADR 1 Steroid decrease HPA AXIS	. 1 TYPE C - chronic
IDENTIFY WHAT TYPE OF ADR 1 Teratogenicity, Carcinogenesis	. 1 TYPE D - Delayed
IDENTIFY WHAT TYPE OF ADR 1 Precipitation of MI by BETA BLOCKER Withrawal	. 1 TYPE E - End of use
IDENTIFY WHAT TYPE OF ADR 1 OCP Failure	. 1 TYPE F - Failure
FDA Serious ADR	1 RESULT IN DEATH 2 LIFE THREATENING 3 REQUIRE HOSPITALIZATION 4 PROLONG HOSPITALIZATION 5 CAUSE DISABILITY 6 CAUSE CONGENITAL ANOMALIES 7 REQUIRE INTERVENTION TO PREVENT PERMANENT INJURIES