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level: Wound Healing

Questions and Answers List

level questions: Wound Healing

Question	Answer
Possess stem cells for continuous regeneration of tissue (eg. skin, small and large bowels, bone marrow)	Labile tissues
Marker for hematopoietic stem cells	CD34
Cells in quiescent stage but may be induced to reenter cell cycle (eg. Liver)	Stable tissues
Lacks significant regenerative potential (eg. Myocardium, skeletal muscle, neurons)	Permanent tissues
Replacement of damaged tissue with fibrous scar	Tissue repair
Tissue formed during the initial phase of repair consisting of fibroblasts, capillaries and myofibroblasts	Granulation tissue
Cells which deposit type III collagen during tissue repair	Fibroblasts
Provides nutrients needed for tissue repair	Capillaries
Contracts wound during tissue repair	Myofibroblasts
High tensile strength collagen found in bone	Type I
Collagen found in cartilage	Type II
Pliable tissue collagen found in blood vessels, granulation tissue and embryonic tissue	Type III
Collagen found in basement membrane	Type IV
Removes Type III collagen in granulation tissue to allow replacement with Type I collagen	Collagenase
Necessary cofactor for collagenase	Zinc
Mediator for epithelial and fibroblast growth factor	TGF alpha
Important fibroblast growth factor; inhibits inflammation	TGF beta
Growth factor for endothelium, smooth muscles and fibroblasts	PDGF
Important for angiogenesis, mediates skeletal development	FGF
Important for angiogenesis	VEGF
Healing wherein wound edges are brought together, leading to minimal scar formation	Healing with primary intention
Healing where edges are not approximated; Granulation tissue fills defect and myofibroblasts contract forming scar	Healing with secondary intention
Most common infectious agent causing delayed wound healing	Staph aureus
Important cofactor in hydroxylation of lysine and proline residues for collagen crosslinking	Vitamin C
Important cofactor for lysyl oxidace responsible for crosslinking lysine and hydroxylysine to form collagen	Copper
Rupture of wound especially in abdominal surgery	Dehiscence
Excess scar tissue localized within wound; excessive Type I collagen	Hypertrophic scar
Excess scar tissue extending beyond wound; excessive Type III collagen	Keloid
Most common location of keloids	Earlobe, face, upper extremities