What are the Licensing Factor that Bind to ORC?

The ORC is a protein complex that is associated with yeast origins throughout the cell cycle. • Cdc6 protein is an unstable protein that is synthesized only in G1. • Cdc6 binds to ORC and allows MCM proteins to bind. • Cdt1 facilitates MCM loading on origins. •When replication is initiated, Cdc6 and Cdt1 are displaced. The degradation of Cdc6 prevents reinitiation.