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HUMAN EMBRYOLOGY

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Question:

Describe the process of intramembranous ossification

Author: Nontoe Nonoe



Answer:

-starts when mesenchymal cells in the center of the region where the bone is about to develop cluster together and differentiate directly into osteoblasts at the primary ossification center -Osteoblast cells then begin to secrete a substance called osteoid, eventually trapping themselves in small cavities called lacunae -The osteoblasts then become osteocytes. -The osteoid secreted by the osteoblasts will accumulate between the embryonic blood vessels in the region, forming bone with a sponge-like appearance. -On the edges of the spongy, woven bone,mesenchyme will condense to form the periosteum(outermost layer of the bone) -Directly adjacent to the periosteum the trabeculae will thicken and be replaced by lamellar bone to form a compact layer of bone b/n the outer periosteal and inner trabecular portions of the bone - The trabecular on the inside do not change, and are referred to as the diploe of the flat bones. Blood vessels remaining in the trabeculae later become the red marrow


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-starts when mesenchymal cells in the center of the
region where the bone is about to develop cluster together and differentiate directly into osteoblasts at the primary ossification center 
-Osteoblast cells then begin to secrete a substance called osteoid, eventually trapping themselves in small cavities called lacunae
-The osteoblasts then become osteocytes.
-The osteoid secreted by the osteoblasts will accumulate between the embryonic blood vessels in the region, forming bone with a sponge-like appearance.
-On the edges of the spongy, woven bone,mesenchyme will condense to form the periosteum(outermost layer of the bone) 
-Directly adjacent to the periosteum the trabeculae will thicken and be replaced by lamellar bone to form a compact layer of bone b/n the outer periosteal and inner trabecular portions of the bone
- The trabecular on the inside do not change, and are referred to as the diploe of the flat bones. Blood vessels remaining in the trabeculae later become the red marrow
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