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From course:

Immunology ch12

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Question:

Examples of mutations that lead to hyper IgM syndrome

Author: Shay 1vcc



Answer:

Caused by mutations in the X chromosome gene encoding CD40 ligand (CD40L) expressed in T cells mutations affecting the enzyme activation-induced deaminase (AID), which is involved in B cell isotype switching and affinity maturation


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Shay 1vcc
Shay 1vcc