Hyperthermia, Hypertension, Tachycardia and Tachypnea, agitation, hyperreflexia and clonus, diaphoresis, vomit, diarrhea Due to therapeutic, drug interaction of OD of seratonin. Triggers: Amphetamine, cocaine, detromethorphan, cyclobenzaprine, triptans, fentanyl, lithium Treatment: supportive. Cyproheptadie is antidote, serotonin antagonist.