BBS2001 Threats and Defence Mechanisms: what happens during margination/tight binding of phagocyte extravasation?

Question

what happens during margination/tight binding of phagocyte extravasation?

Mirte Schattorie · Accepted Answer

a chemokine binds to its receptor on the leukocyte, which causes a conformation change of the leukocyte integrins. this increases the adhesiveness of the leukocyte.

endothelial cells release intracellular adhesion molecules (ICAMs), ICAMs bind the leukocyte tightly to the endothelium.

BBS2001 Threats and Defence Mechanisms

What happens during margination/tight binding of phagocyte extravasation?

A chemokine binds to its receptor on the leukocyte, which causes a conformation change of the leukocyte integrins. this increases the adhesiveness of the leukocyte. endothelial cells release intracellular adhesion molecules (ICAMs), ICAMs bind the leukocyte tightly to the endothelium.

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