BBS2001 Threats and Defence Mechanisms: how do PMs activate the local inflammatory response?

Question

how do PMs activate the local inflammatory response?

Mirte Schattorie · Accepted Answer

1. the PMs are sensed by PRRs
2. the alveolar macrophages release TNF-alpha, IL-1beta, IL-6, IL-8 and granulocyte macrophage colony-stimulating factor (GM-CSF)
3. macrophages can become antigen-presenting cells
4. alveolar and airway epithelial cells are stimulated to produce chemokines

BBS2001 Threats and Defence Mechanisms

How do PMs activate the local inflammatory response?

1. the PMs are sensed by PRRs 2. the alveolar macrophages release TNF-alpha, IL-1beta, IL-6, IL-8 and granulocyte macrophage colony-stimulating factor (GM-CSF) 3. macrophages can become antigen-presenting cells 4. alveolar and airway epithelial cells are stimulated to produce chemokines

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