Drug induced Pre-renal AKI pathophysiology

Decreased Renal blood flow -> leads to increase in vasodilating prostaglandins to dilate the afferent arteriole. Blunted by NSAIDS that inhibit prostaglandin production Decreased Renal blood flow-> leads to Angiotensin 2 constricting the efferent arteriole. Blunted by ACE inhibitors/ARBs that inhibit angiotensin 2 production Both processes overcome by sever hypovolaemia