Nephrotic Syndrome Definition

The definition of nephrotic syndrome includes both massive proteinuria (≥3.5 g/day) and hypoalbuminaemia (serum albumin ≤30 g/L). Increased permeability of the glomerulus leading to loss of proteins into the tubules. This leads to the loss of significant volumes of protein via the kidneys (proteinuria) which results in hypoalbuminaemia.