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From course:

Metabolism Diseases

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Question:

Why Alcoholics May Have Fasting Hypoglycaemia and Gout?

Author: Satvika Sinha



Answer:

• Liver cells unable to use lactate and glycerol for de novo synthesis of glucose (+ poor diet - low glycogen levels) • Reduced levels of NAD+ in liver for conversion of lactate to pyruvate and for glycerol conversion to DHAP • Increased blood lactate leads to lactic acidosis and reduces the kidney’s ability to excrete uric acid; as uric acid levels increase, crystals of urate accumulate in tissues leading to gout


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