Half like of 5h-5d. Increase in infection. Receptors are present for chemotactic factors. Multilobed nucleus. Primary responders. 3 granulocyte types. MPO granule converts H2O to other molecules, NE /Cathepsin and G-proteins act on bacteria. Kill by phagocytosis. Lysosome fuses with phagosome to form phagolysosome. Granule contents are detected and are killed and digested by enzymes. Can also form Nets, the nuclear DNA is discharged and entraps microbes. Made from GMP with G-CSF, IL-2 &3 and C/EbPa.