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LF263 Evolution L13-14

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Question:

SNPs freq shows the basis for Tibetan adaptation to altitude

Author: Alex Rapai



Answer:

EPAS1 is a transcription factor associated with hypoxia – linked to high erythrocyte count Han and Tibetan populations estimated to have diverged 2750 years ago (Fst = 0.026, fairly low differentiation) Fastest selective sweep identified to date


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