The cap binding complex (eIF-4F) in eukaryotes

EIF4E binds 5’ cap. eIF-4A is an ATP-dependent RNA helicase that removes secondary structure near the 5’ end. Needed for scanning movement of the 40S subunit along the mRNA. eIF-4G is a 'scaffold' subunit. links together the initiation complex. Cleavage by protease results in inhibition of initiation.