Regulation of protein synthesis during the cell cycle

G2/M transition decreases 75% total protein synthesis. Caused by cell cycle-dependent dephosphorylation of eIF-4E (Cap binding). Decrease affinity of ribosomes for the cap. IRES-containing RNAs are unaffected. Relative IRES translation rates increase in M phase. In apoptosis, eIF-4G is cleaved: caspase 3, all translation decreases.