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From course:

MCB L9-10

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Question:

Hsc70 action

Author: Alex Rapai



Answer:

Hsc70 does not actively FOLD a protein, but binds and shields its hydrophobic regions and thus prevents AGGREGATION of nascent or unfolded proteins. A partially-folded Hsc70 client protein may be: released, and find its stable conformation, passed on to other chaperones for further folding, released, in preparation for transport, or passed to proteasomes for degradation


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