Intrinsic pathway

Cytochrome c originates from mitochondria, Activating formation of apoptosome. Apoptosome assembly and activation by cytochrome c: -CARD – caspase recruitment domain -NB-ARC – nucleotide oligomerisation domain -> hydrolyses ATP -Winged helix domain – interacts with (d)ATP / (d)ADP -> ATPase – hydrolyses bound ATP. -WD40 repeat – repeat sequence of ~40 aa; repeats form circular β-propeller structures -> involved in cytochrome c binding