II Sporotrichosis

Primarily a chronic mycotic infection of the cutaneous or subcutaneous tissues and adjacent lymphatics. Nodular regions which may ulcerate. Traumatic implantation on skin and secondary spread to joints, bones and muscles. Pulmonary sporotrichosis: caused by the inhalation of conidia, non-specific symptoms. Diagnosis : Tissue biopsy will contain very low numbers of narrow base budding yeast cells. Treatment: Cutaneous lesions respond well to saturated potassium iodide itraconazole & terbinafine have also proved to be effective. Terbinafine an allylamine - a synthetic antifungal agent it is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues.,Terbinafine inhibits ergosterol biosynthesis via inhibition of squalene epoxidase.