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Biology A level

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Question:

Increased methylation of DNA

Author: Eva K 3sq0



Answer:

Methylation is the addition of a methyl group (CHy) to a molecule. In this case the methyl group is added to the cytosine bases of DNA. Methylation normally inhibits the transcription of genes in two ways. o preventing the binding of transcriptional factors to the DNA o attracting proteins that condense the DNA-histone complex (by inducing deacetylation of the histones) making the DNA inaccessible to transcription factors.


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