Third-Generation Cephalosporins: Dosage/Route: Adult: 1 g q8-12h IM or IV; reduce dose with renal impairment Pediatric: 30-50 mg/kg q8-12h IM or IV Usual Indications: Treatment of moderate to severe skin, urinary tract, and respiratory tract infections; intra-abdominal infections; septicemia; bone infections; CNS infections