Domperidone: -Class -Pathophysiology -Problems

-Anti-emetic -Acts at the chemoreceptor trigger zone – used for relief of nausea & vomiting -Doesn’t cross BBB readily- alternative to metoclopramide (which does cross BBB- causes sedation + dystonic reactions) -Known to increase risk of arrhythmias or sudden cardiac death- risk is higher in older people over 60 yrs + those who receive daily oral doses of above 30 mg -Reduce treatment length + dose in older people -Domperidone should be avoided in patients who are taking concomitant medication known to cause QT prolongation (such as ketoconazole and erythromycin).