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Unit 3 Part 2 - Ch 18: Gene Expression Regulation
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Question:
Positive Gene Regulation? Activator?
Author: AMRIT KAURAnswer:
- Some operons are also subject to positive control through a stimulatory protein, called an activator of transcription - When glucose (a preferred food source of E. coli) is scarce, a specific activator attaches to the promoter of the lac operon and increases the affinity of RNA polymerase, thus accelerating transcription - When glucose levels increase, the activator detaches from the lac operon, and transcription returns to a normal, low level - The ability to catalyze compounds like lactose enables cells deprived of glucose to survive
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