Prednisolone: -Class -Indication -Side effects -Risk -Withdrawal

-Corticosteroids -COPD exacerbations, IBD -Short-term: insomnia, mood disturbances, GI disturbances – Long-term: same as short-term and… osteoporosis, adrenal suppression, cushingoid state, diabetes, ocular effects (cataracts/glaucoma), skin changes (e.g. thinning, bruising), GI ulceration, growth retardation, hypokalaemia, fluid retention -If on long courses/high doses- may be immunocompromised– at risk of infection -Must be tapered down gradually if: • >3 weeks any dose • >40mg prednisolone (or equivalent) for more than 1 week • Multiple recent repeated courses • Short course within a year of stopping a long course • Been given repeat doses in the evening – If stopped abruptly- can cause adrenal suppression