Preformulation Studies

1 Physical Description 2 Microscopic Examination 3 Heat of Vaporization 4 Melting Point Depression 5 Phase Rule 6 Particle Size 7 Polymorphism 8 Solubility 9 Dissolution 10 Membrane Permeability 11 Partition Coefficient 12 pKa / Dissociation Constants 13 Hydrates and Solvates 14 Organic Salt Considerations 15 Organic Ester Consideration