Advantages of TDDSs

1 AVOID GASTROINTESTINAL DRUG ABSORPTION DIFFICULTIES caused by gastrointestinal pH, enzymatic activity and drug interactions with food, drink, or other orally administered drugs. 2 SUBSTITUTE FOR ORAL ADMINISTRATION of medication when that route is unsuitable, as in instances of vomiting and/or diarrhea. 3. AVOID FIRST-PASS EFFECT 4. NONINVASIVE, AVOIDING THE INCONVENIENCE OF PARENTERAL THERAPY 5. EXTENDED THERAPY WITH SINGLE APPLICATION, thereby improving patient compliance over other dosage forms requiring more frequent dose administration. 6. The activity of drugs having short half-lives is extended through the reservoir of drug present in the therapeutic delivery system and its controlled release characteristics. 7 Drug therapy may be terminated rapidly by removal of the application from the surface of the skin. 8 Ease of rapid identification of the medication in emergencies (e.g., nonresponsive, unconscious, or comatose patient) due to the physical presence of TDDS