DDS LEC FINALS: 1 Physiologic factors affecting the absorption of drugs from rectal suppositories

2 Physicochemical factors

Question

1 Physiologic factors affecting the absorption of drugs from rectal suppositories

2 Physicochemical factors

LEIGHTON DWIGHT OBILLOS · Accepted Answer

1 Colonic content (Emptier, the more absorption), 
Circulation route (Avoids first pass effect), 
pH and lack of buffering capacity of the rectal fluids

2 Lipid-water solubility, Particle Size, Nature of the base

Mnemonic: CCP, LPN

DDS LEC FINALS

1 Physiologic factors affecting the absorption of drugs from rectal suppositories 2 Physicochemical factors

1 Colonic content (Emptier, the more absorption), Circulation route (Avoids first pass effect), pH and lack of buffering capacity of the rectal fluids 2 Lipid-water solubility, Particle Size, Nature of the base Mnemonic: CCP, LPN

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