How does blood flow influence drug distribution?

Blood flow varies among organs and tissues. An example is propofol (anesthetic which is very lipophilic goes directly to the brain and crosses BBB easily, exerts action for 15 min since after it crosses barrier easily blood should equilibrate it so the drugs entering brain will go back to the blood and after this much time exert action on other tissues Blood flow is also related to the organ mass so we should look at normalized blood flow (ml/kg/min