What are the auto-antibodies seen in RA?

Rheumatoid Factor (RF): targets Fc of IgG, not very specific but sensitive (60-70%) Anti-Citrullinated Peptide Ab (ACPA/ Anti CCP): Attacks citrullinated aa at peptides (arginine), occurs in lungs due to smoking and causes RA, These Ab are highly specific for RA only and is as sensitive as RF. Can be detected pre clinical RA, confirms RA