Endocrinology: What are the possible pathways of developing vascular complications of T2DM?

Question

What are the possible pathways of developing vascular complications of T2DM?

H K · Accepted Answer

Sorbitol pathway decreases antioxidants and thus increases free radicals and thrombotic effect.
Glucose auto oxidation results in a state of oxidative stress.
AGE pathway (CVD, stroke, neuropathy and amputation, nephropathy and retinopathy)

Endocrinology

What are the possible pathways of developing vascular complications of T2DM?

Sorbitol pathway decreases antioxidants and thus increases free radicals and thrombotic effect. Glucose auto oxidation results in a state of oxidative stress. AGE pathway (CVD, stroke, neuropathy and amputation, nephropathy and retinopathy)

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