BIOPHARMACEUTICS: a RESULT OF CHEMICAL ACTIVATION OF THE DRUG, which then ATTACHES STRONGLY TO THE PROTEIN or macromolecule by COVALENT CHEMICAL BONDING.

It ACCOUNTS FOR CERTAIN TYPES OF DRUG TOXICITY that may occur over a long time period

For example, the hepatotoxicity of high doses of
acetaminophen is due to the formation of reactive
metabolite intermediates that interact with liver
proteins.

Question

a RESULT OF CHEMICAL ACTIVATION OF THE DRUG, which then ATTACHES STRONGLY TO THE PROTEIN or macromolecule by COVALENT CHEMICAL BONDING.

It ACCOUNTS FOR CERTAIN TYPES OF DRUG TOXICITY that may occur over a long time period

For example, the hepatotoxicity of high doses of
acetaminophen is due to the formation of reactive
metabolite intermediates that interact with liver
proteins.

LEIGHTON DWIGHT OBILLOS · Accepted Answer

Irreversible drug–protein binding

BIOPHARMACEUTICS

Irreversible drug–protein binding

Author