What are the predictors of disease severity?

Our management of the disease is purely symptomatic Most important score of evaluation is SIRS (systemic inflammatory response syndrome) where we see if we have a sever acute pancreatitis by seeing other organs involvement, SIRSS 2 of 4 criteria (pulse >90 bpm, Rectal Temp <36 or >38, WBC <4000 or >12000, RR >20 or Pco2 <32 mmHg We also use scores like APACH (in ICU since it takes time (48 hours)) We could see CRP as well At a cutoff of 21 mg/dL, the sensitivity of CRP in detecting severe disease in patients with acute pancreatitis is only 60%, but the test is highly specific. At a lower cutoff (10 mg/L), CRP becomes highly sensitive, but the test specificity drops to 75%.