What is the importance of conjugation reactions on neonatology?

Glucuronidation increases molecular weight of a compound favoring biliary excretion. UDPGT for example facilitates bilirubin conjugation and excretion, a deficiency in this enzyme will lead to neonatal jaundice which results in increased unconjugated bilirubin, this will also cause underdeveloped BBB due to binding of unconjugated bilirubin to CNS causing significant damage as well this is called bilirubin encephalopathy